Remyelination — An effective means of neuroprotection |
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Authors: | Charlotte C Bruce Chao Zhao Robin JM Franklin |
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Institution: | a Cambridge Centre for Brain Repair, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK b MRC Cambridge Centre for Stem Cell Biology and Regenerative Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK c Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK |
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Abstract: | Remyelination following central nervous system (CNS) demyelination restores rapid saltatory conduction of action potentials and contributes to the maintenance of axonal integrity. This robust regenerative phenomenon stands in contrast to the limited repair capacity that is characteristic of CNS neuronal injury. However, despite its efficiency in experimental models and some clinical diseases, remyelination failure becomes an increasingly pronounced feature of the pathology of chronic multiple sclerosis (MS) lesions. Chronic demyelination predisposes axons to atrophy, an irreversible event that is a major pathological correlate of progressive functional decline. This has created a compelling case for developing therapies that promote remyelination: evidence from experimental animal models suggests that hormones may have a beneficial role to play in this regard. |
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Keywords: | Remyelination Regeneration Stem cells Myelin Axon Multiple sclerosis Hormone |
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