In vitro transformation of cheno- and ursodeoxycholic acids and their 7-oleyl esters by human intestinal microflora |
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| Authors: | A Ferrari N Pacini C R Sirtori D Kritchevsky |
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| Institution: | Department of Food Science and Microbiology, University of Milan, Italy. |
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| Abstract: | Chenodeoxycholic and ursodeoxycholic acid are used widely for the treatment of gallstones. A possible drawback to their utility is their conversion to lithocholic acid, which has displayed histotoxicity and mutagenicity. The 7-oleyl esters of cheno- and ursodeoxycholic acid are not degraded by fecal bacteria and may represent safer means of treatment. |
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