Production of aminoglycosides in non-aminoglycoside producing Streptomyces lividans TK24 |
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| Authors: | Subba Bimala Kurumbang Nagendra Prasad Jung Young Soo Yoon Yeo Joon Lee Hei Chan Liou Kwangkyoung Sohng Jae Kyung |
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| Institution: | Institute of Biomolecule Reconstruction (IBR), Department of Pharmaceutical Engineering, Sun Moon University, #100, Kalsan-ri, Tangjeong-myeon, Asansi, Chungnam 336-708, Republic of Korea. |
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| Abstract: | The pRBM4 cosmid, which harbors a putative cluster of genes spanning a 31.8-kb chromosomal region of the ribostamycin producer Streptomyces ribosidificus ATCC 21294, was heterologously expressed in Streptomyces lividans TK24. ESI-MS/MS, HPLC, and LC-ESI MS analyses showed that the transformation gave rise to ribostamycin production in various culture broths. This is the first report of heterologous aminoglycoside production. |
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