Soy isoflavone equol perpetuates dextran sulfate sodium-induced acute colitis in mice |
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| Authors: | Sakai Tohru Furoku Sakina Nakamoto Mariko Shuto Emi Hosaka Toshio Nishioka Yasuhiko Sone Saburo |
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| Institution: | Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. tohrus@nutr.med.tokushima-u.ac.jp |
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| Abstract: | The effects of the soy isoflavones, genistein, daidzein and equol, on experimental colitis were examined. Equol severely perpetrated dextran sulfate sodium (DSS)-induced colitis as evaluated by the weight loss. Production of the anti-inflammatory cytokine, IL-10, from T cells was decreased in the equol-treated mice. The results show that the soy isoflavone, equol, played an important role in the inflammatory response in the gastrointestinal tract. |
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