In situ detection of calcium ions with chemically modified microcantilevers |
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Authors: | Ji Hai Feng Thundat Thomas |
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Institution: | Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6123, USA. |
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Abstract: | We report a novel technique of micromechanical detection of trace amounts of calcium ions by using microcantilevers modified with ion-selective self-assembled monolayers (SAMs). The SAM-modified microcantilevers undergo bending due to selective adsorption of calcium ions. Experiments conducted under flow conditions show that the modified cantilevers respond sensitively to calcium ions (Ca(2+)); a Ca(2+) concentration of 10(-9) M can be detected with this technique. Other cations, such as Na(+) and K(+), do not have any effect on the deflection of these cantilevers. We demonstrate two different kinds of SAMs having selectivity for calcium ions. |
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