Studies on L-arginase in developing rat small intestine, brain, and kidney. II. Effect of hydrocortisone and thyroxine |
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| Authors: | L Konarska L Tomaszewski U Rolczyk |
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| Institution: | 1. School of Transportation Science and Engineering, Beihang University, 37 Xueyuan Road, Haidian District, Beijing 100191, China;2. Lightweight Vehicle Innovation Center, Beihang University, 37 Xueyuan Road, Haidian District, Beijing 100191, China;3. Zhengzhou Electromechanical Engineering Research Institute, Zhengzhou, Henan 450015, China;1. Centre for Advanced Mechanisms and Robotics, School of Mechanical Engineering, Tianjin University, Tianjin 300354, China;2. Division of Medical Physics, Department of Radiation Oncology, Thomas Jefferson University, Kimmel Cancer Center, 111 South 11th Street, Philadelphia PA 19107, USA;3. Tianjin Medical University Cancer Institute and Hospital, Huanhu West Road, Hexi District, Tianjin 300060, China |
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| Abstract: | The influences of hydrocortisone and thyroxine on the developmental changes of arginase activity in intestine, kidney, and brain of suckling rats were studied. A single injection of hydrocortisone (50 mg/kg) into rats aged 9 days evoked premature increase of jejunal arginase activity due to precocious formation of arginase A4. Arginase A4 can be detected about 48 hr after hydrocortisone injection, whereas in intact rats the enzyme appears in the intestinal mucosa on the 19th-21st days of postnatal life. After hydrocortisone administration to rats aged 6 days, a similar pattern of arginase activity in jejunum was observed. Under the same conditions, the influence of hydrocortisone on kidney arginase was weaker. The hormone did not have any influence on the activity of brain arginase. Daily injection of thyroxine (2 mg/kg) to 6-day-old rats (for 6 consecutive days) caused a precocious increase of the arginase activity in intestine. Under the same conditions, only a slight increase of the arginase activity was observed in kidney, whereas in brain the activity was unaffected. |
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