Periodontopathic bacterial endotoxin-induced tumor necrosis factor alpha production was inhibited by exercise in mice |
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Authors: | Kato Tetsuo Kaneko Sachiko Kimizuka Ryuta Okuda Katsuji |
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Institution: | Department of Microbiology, Oral Health Science Center, Tokyo Dental College, Chiba, Japan. tekato@tdc.ac.jp |
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Abstract: | The effects of exercise on serum interleukin-6 and tumor necrosis factor alpha levels were investigated using mice. Five-week-old female BALB/c mice (Th2-biased) and C57BL/6 mice (Th1-biased) were divided into exercise and control groups. The exercise group was exercised in a rotating basket type treadmill for 1 h (5 r.p.m.). Blood was collected and the serum was separated immediately after exercise. The serum interleukin-6 and tumor necrosis factor alpha levels were measured using an Endogen ELISA kit. Exercise significantly increased the serum interleukin-6 level in the two strains of mice (P<0.05 and P<0.01). The tumor necrosis factor alpha level was decreased in the exercise group. Next, periodontopathic bacterial endotoxin (lipopolysaccharide) was administered after exercise, and the effects of exercise on the lipopolysaccharide-induced serum interleukin-6 and tumor necrosis factor alpha levels were investigated. Exercise inhibited lipopolysaccharide-induced tumor necrosis factor alpha production, suggesting it has a defensive action against endotoxin shock. |
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Keywords: | periodontopathic bacteria endotoxin interleukin-6 tumor necrosis factor α exercise |
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