Investigation of lipid peroxidation in liposomes induced by heavy ion irradiation |
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Authors: | C Ziegler J M Wessels |
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Institution: | (1) Experimentalphysik III, Fachbereich 18, Gesamthochschule Kassel, Postfach 101380, D-34109 Kassel, Germany, DE;(2) GSF – National Research Center for Environment and Health, D-85764 Neuherberg, Germany, DE |
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Abstract: | Lipid peroxidation induced by heavy ion irradiation was investigated in 1,2-dilinoleoyl-sn-glycero-3-phosphocholine (DLPC) liposomes. Lipid peroxidation was induced using accelerated heavy ions that exhibit linear
energy transfer (LET) values between 30 and 15 000 keV/μm and doses up to 100 kGy. With increasing LET, the formation of lipid
peroxidation products such as conjugated dienes, lipid hydroperoxides, and thiobarbituric acid-reactive substances decreased.
When comparing differential absorption spectra and membrane fluidity following irradiation with heavy ions and x-rays (3 Gy/min),
respectively, it is obvious that there are significant differences between the influences of densely and sparsely ionizing
radiation on liposomal membranes. Indications for lipid fragmentation could be detected after heavy ion irradiation.
Received: 6 March 1997 / Accepted in revised form: 31 March 1998 |
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