Characterization, origin and evolution of alpha-fetoprotein and albumin in postnatal rat brain

1. The levels of AFP and albumin in rat brain at birth were 77 and 340 micrograms per g of tissue, respectively. These levels quickly dropped with age. AFP was undetectable in 20 days brain extracts whereas 30 micrograms of albumin per g of brain were still measured. 2. AFP from brain and serum were identical by immunodiffusion, electrophoresis and immuno-affinoelectrophoresis with free Concanavalin A. 3. No in vitro synthesis of AFP and albumin in the postnatal brain was observed. However, the total amount of AFP in the developing rat brain increases from birth to 4-5 days post-partum.