Replication of Viral Deoxyribonucleic Acid and Breakdown of Cellular Deoxyribonucleic Acid in Epstein-Barr Virus Infection |
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| Authors: | Meihan Nonoyama and Joseph S. Pagano |
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| Affiliation: | 1Department of Bacteriology and Immunology and Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27514 |
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| Abstract: | Infection of Raji cells with Epstein-Barr virus (EBV) causes suppression of cellular deoxyribonucleic acid (DNA) synthesis and fragmentation of the cellular DNA. About 1,000 copies of EBV DNA of normal size (about 5 x 10(7) daltons in a single strand, as shown in an alkaline gradient) are synthesized per cell. |
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