Mutagenic activity of copper(II) chromate and dichromate complexes with polypyridines |
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| Authors: | Katarzyna Szyba Maria Cieślak Golonka Kazimierz Gasiorowski Joanna Urban |
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| Affiliation: | 1. Department of Basic Medical Sciences, Medical Academy, 51-601, Wroc?aw, Poland
2. Institute of Inorganic Chemistry and Metallurgy of Rare Elements, Technical University, Wroc?aw, Poland
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| Abstract: | Copper(II) chromate and dichromate complexes with 2,2'-bipyridyl and 1,10-phenathroline were tested for their mutagenic activity in the standard Ames test. All of six tested complexes exhibited markedly lower mutagenic activity than the reference compounds--potassium dichromate and sodium chromate. The blockage of Cr(VI) reduction capability in the presence of the complex Cu2+ ion and the competition between copper and chromium ions in the interaction with cellular components are discussed in the light of the results of our previous chemical study. |
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| Keywords: | Ames test chromium mutagenicity polypyridines |
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