Biodistribution of sodium borocaptate (BSH) for boron neutron capture therapy (BNCT) in an oral cancer model |
| |
Authors: | Marcela A Garabalino Elisa M Heber Andrea Monti Hughes Sara J González Ana J Molinari Emiliano C C Pozzi Susana Nievas Maria E Itoiz Romina F Aromando David W Nigg William Bauer Verónica A Trivillin Amanda E Schwint |
| |
Affiliation: | 1. Department of Radiobiology, National Atomic Energy Commission (CNEA), Avenida General Paz 1499, B1650KNA, San Martin, Buenos Aires, Argentina 3. Department of Instrumentation and Control, National Atomic Energy Commission (CNEA), Avenida General Paz 1499, B1650KNA, San Martin, Buenos Aires, Argentina 7. National Research Council (CONICET), Buenos Aires, Argentina 2. Department of Research and Production Reactors, National Atomic Energy Commission (CNEA), Presbítero Juan González y Aragon 15, B1802AYA, Ezeiza, Buenos Aires, Argentina 4. Department of Chemistry, National Atomic Energy Commission (CNEA), Avenida General Paz 1499, B1650KNA, San Martin, Buenos Aires, Argentina 5. Department of Oral Pathology, Faculty of Dentistry, University of Buenos Aires, Marcelo T. de Alvear 2142, 1122, Ciudad Autónoma de Buenos Aires, Argentina 6. Idaho National Laboratory, 2525 North Fremont Street, P.O. Box 1625, Idaho Falls, ID, 83415, USA
|
| |
Abstract: | Boron neutron capture therapy (BNCT) is based on selective accumulation of 10B carriers in tumor followed by neutron irradiation. We previously proved the therapeutic success of BNCT mediated by the boron compounds boronophenylalanine and sodium decahydrodecaborate (GB-10) in the hamster cheek pouch oral cancer model. Based on the clinical relevance of the boron carrier sodium borocaptate (BSH) and the knowledge that the most effective way to optimize BNCT is to improve tumor boron targeting, the specific aim of this study was to perform biodistribution studies of BSH in the hamster cheek pouch oral cancer model and evaluate the feasibility of BNCT mediated by BSH at nuclear reactor RA-3. The general aim of these studies is to contribute to the knowledge of BNCT radiobiology and optimize BNCT for head and neck cancer. Sodium borocaptate (50 mg 10B/kg) was administered to tumor-bearing hamsters. Groups of 3–5 animals were killed humanely at nine time-points, 3–12 h post-administration. Samples of blood, tumor, precancerous pouch tissue, normal pouch tissue and other clinically relevant normal tissues were processed for boron measurement by optic emission spectroscopy. Tumor boron concentration peaked to therapeutically useful boron concentration values of 24–35 ppm. The boron concentration ratio tumor/normal pouch tissue ranged from 1.1 to 1.8. Pharmacokinetic curves showed that the optimum interval between BSH administration and neutron irradiation was 7–11 h. It is concluded that BNCT mediated by BSH at nuclear reactor RA-3 would be feasible. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|