Ferritin H and L mRNAs in human neoplastic tissues |
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| Authors: | M A Bevilacqua F Costanzo L Buonaguro F Cimino |
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| Affiliation: | Istituto di Scienze Biochimiche, II Facoltà di Medicina e Chirurgia, Università di Napoli. |
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| Abstract: | The typical tissue isoferritin pattern varies during neoplastic transformation, usually shifting toward a more acidic profile. To investigate the molecular basis of this phenomenon, we have analyzed the steady-state levels of the H and L mRNAs in several neoplastic tissues. By using specific probes for the two ferritin subunits, we have found, in three different adenocarcinomas and in a case of Hodgkin lymphoma, a two- to four-fold increase of the H and L mRNA levels compared to those found in normal human liver. |
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