Does ‘Immortal DNA strand' exist in ‘immortal' stem cells? |
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作者姓名: | Li L |
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作者单位: | Stowers Institute for Medical Research, Kansas City, MO 64110, USA. |
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摘 要: | Stem cells function to generate differentiated cells, and, at the same time, are maintained as ‘immortal' cells through self-renewal. Accumulated evidence indicates that adult stem cells may be the most common precursor for cancers in adult mammalian tissue , and this concept is gaining increasing support . Meanwhile, this also raises the question of how stem cells, which have a much longer lifespan compared to other progenitor and mature cells, can avoid accumulating mutations from DNA replication errors, thereby reducing the risk of tumorigenesis.第一段]
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关 键 词: | 干细胞 DNA 成熟细胞 细胞突变 |
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