| RNAi技术研究进展及其在医学中的应用前景 |
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| 引用本文： | 范守城,张云茹. RNAi技术研究进展及其在医学中的应用前景[J]. 微生物学杂志, 2009, 29(4): 93-98 |
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| 作者姓名： | 范守城 张云茹 |
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| 作者单位： | 1. 重庆市生产力促进中心,重庆,401147
2. 重庆工学院,生物工程学院,重庆,400050 |
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| 摘 要： | 将双链RNA导入细胞内会引起与其同源基因的沉默，这种现象称为RNA干扰（RNAinterference，RNAi）。就RNAi技术的定义、发现过程、作用机制、产生机理等方面的研究进展作一综述，同时对RNAi技术在医学领域中的应用和存在问题进行了展望。
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| 关 键 词： | RNAi技术 双链RNA 基因沉默 基因治疗 |
Research Progress on RNAi Technique and its Application Prospect in Medicine |
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| FAN Shou-cheng,ZHANG Yun-ru. Research Progress on RNAi Technique and its Application Prospect in Medicine[J]. Journal of Microbiology, 2009, 29(4): 93-98 |
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| Authors: | FAN Shou-cheng ZHANG Yun-ru |
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| Affiliation: | FAN Shou-cheng, ZHANG Yun-ru(1. Chongqing Productivity center, Chongqing city, 401147 ;2. Chongqing Institute of Technology bioengineering institute Chongqing city ,400050 ) |
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| Abstract: | Transfer of double-stranded RNA into cells can cause the silence of homologous gene, and this phenomenon is called as RNA interference （RNA interference, RNAi）. In this paper, the definition of RNAi technique, the discovery process and the mechanisms of action and generation of RNAi are reviewed. At the same time the applications and problems of RNAi technique in madieine in future were prospected. |
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| Keywords: | RNAi technique double-stranded RNA gene silence gene therapy |
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