Inhibition of protein secretion and protein kinase activity in the locust fat body by diamide (Azodicarboxylic acid-bis-dimethylamide) |
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| Authors: | Paula Harry Mark Pines Shalom W Applebaum |
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| Institution: | Department of Entomology, Faculty of Agriculture, The Hebrew University of Jerusalem, Rehovot 76 100, Israel |
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| Abstract: | Protein secretion from locust fat body incubated in vitro is instantaneously halted in the presence of diamide (azodicarboxylic acid-bis-dimethylamide). Independent inhibition of amino acid uptake, protein synthesis (verified in cell-free systems), and protein secretion is demonstrated. Diamide inhibits cyclic AMP- and cyclic GMP-dependent protein kinase activity in locust fat body. |
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