| c-Met与Fas在胃癌组织中的表达及其相关性 |
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| 引用本文： | 戴光云,刘银华,王洋,朱升学,张盛周.c-Met与Fas在胃癌组织中的表达及其相关性[J].中国组织化学与细胞化学杂志,2009,18(6):678-682. |
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| 作者姓名： | 戴光云 刘银华 王洋 朱升学 张盛周 |
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| 作者单位： | 1. 安徽师范大学生命科学学院,芜湖,241000
2. 皖南医学院弋矶山医院病理科,芜湖,241001 |
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| 基金项目： | 安徽高校省级自然科学研究重点项目，生物环境与生态安全省级重点实验室及安徽省重要生物资源保护与利用重点实验室建设基金 |
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| 摘 要： | 目的探讨c-Met和Fas在胃癌中的表达、临床意义及其相关性。方法采用免疫组化方法检测c-Met和Fas在正常胃黏膜（n=17）,胃癌旁组织（n=51）及胃癌组织（n=51）中的表达。结果在正常胃黏膜、胃癌旁组织及胃癌组织中,c-Met阳性率呈递增趋势,组间差异有统计学意义（χ^219.881,P〈0.01）;Fas阳性率有递减趋势,组间差异有统计学意义（χ^29.590,P〈0.01）。χ^2验显示c-Met在浸润深度和淋巴结转移组内阳性表达率组内差异有统计学意义（P〈0.05）,而在年龄、性别和组织分型组内差异无统计学意义（P〉0.05）;Fas在浸润深度组内阳性表达率组内差异有统计学意义（P〈0.05）,而在年龄、性别、组织分型和淋巴结转移组内差异无统计学意义（P〉0.05）。Spearman等级相关分析显示c-Met和Fas表达呈正相关（rs=0.599,P〈0.01）。结论c-Met过表达和Fas表达下调与胃癌的发生发展及浸润转移有关,c-Met表达可能是胃癌细胞逃逸Fas介导的细胞凋亡的一种机制。
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| 关 键 词： | 胃癌 c-Met Fas 免疫组织化学 |
EXPRESSIONS OF c-Met AND Fas PROTEINS IN GASTRIC CARCINOMA AND THEIR RELATIONSHIP |
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| Dai Guangyun,Liu Yinhua,Wang Yang,Zhu Shengxue,Zhang Shengzhou.EXPRESSIONS OF c-Met AND Fas PROTEINS IN GASTRIC CARCINOMA AND THEIR RELATIONSHIP[J].Chinese Journal of Histochemistry and Cytochemistry,2009,18(6):678-682. |
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| Authors: | Dai Guangyun Liu Yinhua Wang Yang Zhu Shengxue Zhang Shengzhou |
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| Institution: | Dai Guangyun1,Liu Yinhua2,Wang Yang1,Zhu Shengxue1,Zhang Shengzhou1(1College of Life Science,Anhui Normal University,Wuhu 241000,2Department of Pathology,Yijishan Hospital,Wannan Medical College,Wuhu 241001,China) |
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| Abstract: | Objective To investigate the expression and clinical significance of c-Met and Fas gene in human gastric carcinoma and their relationship.MethodsThe expressions of c-Met and Fas were detected by immunohistochemistry among normal gastric mucosa(n=17),adjacent normal tissue(n=51) and gastric carcinoma(n=51).ResultsThe positive expression rate of c-Met protein among normal gastric mucosa,adjacent normal tissue and gastric carcinoma was gradually increased,and statistical differences among the three groups were... |
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| Keywords: | c-Met Fas Gastric carcinoma c-Met Fas Immunohistochemistry |
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