Central effects of neuropeptides on ventilation in the rat |
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| Authors: | D E Niewoehner A S Levine J E Morley |
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| Affiliation: | 1. Pulmonary and Endocrinology Sections, Minneapolis, MN USA;2. VA Medical Center, Minneapolis, MN 55417 USA;3. Department of Medicine University of Minnesota, Minneapolis and St. Paul, MN USA;4. Department of Food Science and Nutrition University of Minnesota, Minneapolis and St. Paul, MN USA |
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| Abstract: | We have examined the effects of centrally applied neuropeptides on ventilation (respiratory rate, tidal volume, and minute ventilation) in urethane-anesthetized rats. TRH caused an increase in respiratory rate, a decrease in tidal volume, but an increase in net minute ventilation. One TRH metabolite, acid TRH, caused similar changes, but no effect was observed from the other TRH metabolite, cHis-Pro. Both bombesin and calcitonin caused increases in minute ventilation due to increases in respiratory rate and tidal volume. Additionally, bombesin induced periodic sighing respirations at rates up to 15/minute which was observed with no other neuropeptide. Substance P, somatostatin, and neurotensin had no effect upon ventilation variables. |
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| Keywords: | TRH Bombesin Calcitonin Substance P Ventilation Somatostatin Neurotensin |
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