Habenular modulation of raphe indoleamine metabolism |
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Authors: | S G Speciale L M Neckers R J Wyatt |
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Affiliation: | 1. Department of Psychiatry, University of Texas Health Science Center at Dallas, Dallas, Texas 75235, USA;1. Laboratory of Clinical Psychopharmacology, Division of Special Mental Health Research, NIMH, saint Elizabeths Hospital, Washington, D.C. 20032, USA |
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Abstract: | Anatomical and neurophysiological findings have demonstrated neuronal connections between the diencephalic habenular nuclei and brain stem serotonergic raphe nuclei. Therefore we examined some neurochemical consequences of habenular lesions. Sixteen hours and one week after bilateral lesions serotonin metabolism (as reflected by concentrations of its metabolite, 5-hydroxyindoleacetic acid) was significantly increased in the dorsal but not the median raphe nuclei. Unilateral lesions produced a proportionally smaller augmentation. Motron locomotor activity was enhanced during the light and dark illumination phases in lesioned animals but only attained statistical significance during the day. |
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