A preliminary genetic analysis of TE146, a very large transposing element of Drosophila melanogaster |
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Authors: | D Gubb J Roote G Harrington S McGill B Durrant M Shelton M Ashburner |
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Institution: | (1) Department of Genetics, University of Cambridge, Cambridge, England |
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Abstract: | TE146 is a transposing element (TE) consisting of six polytene chromosome bands that has inserted into the no-ocelli (noc 2 50) locus. This member of Ising's TE family carries two copies of the white and roughest loci. TE146 is lost from noc with a spontaneous frequency of approximately 1 in 22000 chromosomes. All spontaneous losses are accompanied by the reversion of the noc mutation associated with the TE. The TE is associated with fold-back (FB) sequences. The losses of TE146 retain fold-back homology at noc. Of 26 -ray-induced losses of TE146, 16 are gross deletions, removing loci neighboring noc and ten are not. The non-deleted -ray-induced losses are either noc
– and rst
+ or noc
+ and rst
–. The white+ genes of TE146 are dosage compensated since w/Y; TE146/+ and w/w; TE146/+ flies are sexually dimorphic for eye color. These w
+ genes are also suppressed by zeste since z w; TE146/+ flies have zeste-colored eyes. |
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