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The effects of cell density and metabolite flux on cellular dynamics |
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| Authors: | Hans G Othmer John A Aldridge |
| Institution: | (1) Mathematics Department, Rutgers University, 08903 New Brunswick, NJ, USA;(2) Department of Electrical Engineering, Princeton University, Princeton, NJ, USA;(3) Present address: Department of Pediatrics, Children's Hospital, Boston, MA |
| Abstract: | Summary Density-dependent regulation of cell growth in tissue culture is a well-known phenomenon but the mechanism of regulation remains obscure. Here we explore the effects of cell density and metabolite flux on the collective dynamics of a cell population. The intracellular dynamics are modelled by positive feedback kinetic mechanisms of the kind known to apply to yeast cells. Several experimental observations related to glycolytic oscillations are predicted and it is suggested that the general conclusions may be applicable in a broader context. |
| Keywords: | Glycolytic oscillations Density-dependent growth control |
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