The cell adhesion molecule neurofascin stabilizes axo-axonic GABAergic terminals at the axon initial segment |
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| Authors: | Kriebel Martin Metzger Jennifer Trinks Sabine Chugh Deepti Harvey Robert J Harvey Kirsten Volkmer Hansjürgen |
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| Institution: | From the ‡Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen, 72770 Reutlingen, Germany.;the ¶Department of Pharmacology, the School of Pharmacy, University of London, London WC1N 1AX, United Kingdom, and ;the §Graduate School of Cellular and Molecular Neuroscience, Universität Tübingen, D-72074 Tübingen, Germany |
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| Abstract: | Cell adhesion molecules regulate synapse formation and maintenance via transsynaptic contact stabilization involving both extracellular interactions and intracellular postsynaptic scaffold assembly. The cell adhesion molecule neurofascin is localized at the axon initial segment of granular cells in rat dentate gyrus, which is mainly targeted by chandelier cells. Lentiviral shRNA-mediated knockdown of neurofascin in adult rat brain indicates that neurofascin regulates the number and size of postsynaptic gephyrin scaffolds, the number of GABA(A) receptor clusters as well as presynaptic glutamate decarboxylase-positive terminals at the axon initial segment. By contrast, overexpression of neurofascin in hippocampal neurons increases gephyrin cluster size presumably via stimulation of fibroblast growth factor receptor 1 signaling pathways. |
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| Keywords: | Axon Brain GABA Receptors Gene Silencing Synapses FGFR1 Axon Initial Segment Gephyrin Neurofascin |
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