The use of immunological tolerance to investigate B lymphocyte replacement kinetics in chickens |
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| Authors: | P Klein T Hraba J Dole?al |
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| Institution: | (1) Institute of Microbiology, Czechoslovak Academy of Sciences, Víde ská 1083, 142 20 Praha, Czechoslovakia;(2) Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Vídeská 1083, 142 20 Praha, Czechoslovakia;(3) Institute of Information Theory and Automation, Czechoslovak Academy of Sciences, Podvodárenskou v  i 4, 182 08 Praha, Czechoslovakia;(4) Present address: Laboratory of Theoretical Biology, National Institutes of Health, 20205 Bethesda, MD, USA |
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| Abstract: | A simple mathematical model has been derived, describing the irreversible inactivation of immature B cells by high doses of antigen during induction of tolerance, and the antigen-independent replacement of B cells by differentiation of their precursors. The latter leads to recovery from tolerance, the rate of which can be used to assess the rate of B cell replacement in experiments. The model has been compared with experimental tolerance to human albumin in newly hatched chickens.(1) It has been shown that this tolerance cannot be explained only by elimination of B cells but (2) the computed rate of B cell replacement agreed with the experimental rate assessed by immunization of tolerant chickens with a cross-reacting antigen. (3) In order to further verify the model, additional experiments to test the rate of B cell replacement were suggested by the model. |
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| Keywords: | Immunological tolerance B lymphocyte replacement kinetics Mathematical model |
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