Application of formal methods to biological regulatory networks: extending Thomas' asynchronous logical approach with temporal logic |
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Authors: | Bernot Gilles Comet Jean-Paul Richard Adrien Guespin Janine |
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Institution: | La.M.I., Laboratoire de Méthodes Informatiques, UMR 8042, CNRS & Université d'Evry,Boulevard Fran?ois Mitterrand, 91025 Evry Cedex, France. bernot@lami.univ-evry.fr |
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Abstract: | Based on the discrete definition of biological regulatory networks developed by René Thomas, we provide a computer science formal approach to treat temporal properties of biological regulatory networks, expressed in computational tree logic. It is then possible to build all the models satisfying a set of given temporal properties. Our approach is illustrated with the mucus production in Pseudomonas aeruginosa. This application of formal methods from computer science to biological regulatory networks should open the way to many other fruitful applications. |
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Keywords: | Biological regulatory networks Formal methods Temporal logic Model checking |
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