Nor-sterols in Axinella proliferans, sponge from the Indian Ocean |
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| Authors: | Maurice Aknin Emile M Gaydou Nicole Boury-Esnault Valeria Costantino Ernesto Fattorusso Alfonso Mangoni |
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| Institution: | ?Laboratoire de Chimie Organique, Faculté des Sciences, 15 Avenue René Cassin, BP 7151-97715 Saint-Denis Messag cedex 9, La Réunion, France;?Laboratoire de Phytochimie de Marseille, Faculté des Sciences et Techniques de Saint-Jérôme, Avenue Escadrille Normandie-Niemen 13397 Marseille cedex 20, France;?Centre d'Océanologie de Marseille, Station Merine d'Endoume, Université de La Méditerranée, CNRS URA41, 13007 Marseille, France;§Dipartimento di Chimica delle Sostanze Naturali, via Domenico Montesano 49-I-80131 Napoli, Italia |
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| Abstract: | An examination of the sterol mixture of the sponge Axinella proliferans collected in the Indian Ocean led to the isolation of nine A-nor-sterols, including two rare nor-sterols with a D-ring unsaturation. The known 3β-(hydroxymethyl)-A-nor-5α-cholest-15-ene has been identified by a comparison with mass spectrum and 1H and 13C nuclear magnetic resonance (NMR) data of the sterol isolated from Homoaxinella trachys, a marine sponge collected in the Indian Ocean. A new sterol, 3β-(hydroxymethyl)-A-nor-5α-cholest-14-ene-16α-ol, has been identified by their mass and two-dimensional NMR spectra compared with those of the D-ring unsaturated sterol, 5α-cholest-14-ene-3β,16α-diol isolated from the Mediterannean sponge Topsentia aurantiaca. |
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| Keywords: | Demospongie sponge Axinella proliferans nor-sterols 3β -(hydroxymethyl)-A-nor-5α -cholest-14-ene-16α -ol GC/MS/ NMR Indian Ocean |
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