| Computational Analysis of Cysteine Proteases （Clan CA, Family C1） of Leishmania major to Find Potential Epitopic Regions |
| |
| 作者姓名： | Babak Saffari Hassan Mohabatkar |
| |
| 作者单位： | Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran |
| |
| 基金项目： | supported by a grant (No. 88-GR-SC-47) from Shiraz University |
| |
| 摘 要： | Leishmania is associated with a broad spectrum of diseases, ranging from simple cutaneous to invasive visceral leishmaniasis. Here, the sequences of ten cysteine proteases of types A, B and C of Leishmania major were obtained from GeneDB database. Prediction of MHC class I epitopes of these cysteine proteases was performed by NetCTL program version 1.2. In addition, by using BcePred server, different structural properties of the proteins were predicted to find out their potential B cell epitopes. According ...
|
| 关 键 词： | 半胱氨酸蛋白酶 加利福尼亚 计算 原虫 B细胞表位 家庭 抗原表位 结构性能 |
Computational Analysis of Cysteine Proteases(Clan CA,Family C1) of Leishmania major to Find Potential Epitopic Regions |
| |
| Babak Saffari,Hassan Mohabatkar.Computational Analysis of Cysteine Proteases(Clan CA,Family C1) of Leishmania major to Find Potential Epitopic Regions[J].Genomics Proteomics & Bioinformatics,2009,7(3):87-95. |
| |
| Authors: | Babak Saffari Hassan Mohabatkar |
| |
| Institution: | Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran |
| |
| Abstract: | Leishmania is associated with a broad spectrum of diseases, ranging from simple cutaneous to invasive visceral leishmaniasis. Here, the sequences of ten cysteine proteases of types A, B and C of Leishmania major were obtained from GeneDB database. Prediction of MHC class I epitopes of these cysteine proteases was performed by NetCTL program version 1.2. In addition, by using BcePred server, different structural properties of the proteins were predicted to find out their po- tential B cell epitopes. Accordin... |
| |
| Keywords: | bioinformatics cysteine protease T cell epitope B cell epitope Leishmania major |
| 本文献已被 CNKI 维普 万方数据 ScienceDirect 等数据库收录！ |
