ArrayIDer: automated structural re-annotation pipeline for DNA microarrays |
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Authors: | Bart HJ van den Berg Jay H Konieczka Fiona M McCarthy Shane C Burgess |
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Affiliation: | (1) Department of Basic Science, College of Veterinary Medicine, Mississippi State University, PO Box 6100, Mississippi State, MS 39762, USA;(2) Instistute for Digital Biology, Mississippi State University, Mississippi State, MS 39762, USA;(3) Department of Molecular & Cellular Biology, University of Arizona, 1656 E. Mabel, MRB 317, Tucson, AZ 85724, USA;(4) Life Sciences and Biotechnology Institute, Mississippi State University, Mississippi State, Mississippi 39762, USA |
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Abstract: | Background Systems biology modeling from microarray data requires the most contemporary structural and functional array annotation. However, microarray annotations, especially for non-commercial, non-traditional biomedical model organisms, are often dated. In addition, most microarray analysis tools do not readily accept EST clone names, which are abundantly represented on arrays. Manual re-annotation of microarrays is impracticable and so we developed a computational re-annotation tool (ArrayIDer) to retrieve the most recent accession mapping files from public databases based on EST clone names or accessions and rapidly generate database accessions for entire microarrays. |
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