Reconstruction of Escherichia coli transcriptional regulatory networks via regulon-based associations |
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| Authors: | Hossein Zare Dipen Sangurdekar Poonam Srivastava Mostafa Kaveh Arkady Khodursky |
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| Affiliation: | (1) Department of Electrical and Computer Engineering, The University of Minnesota, Minneapolis, MN, USA;(2) Department of Biochemistry, Biophysics and Molecular Biology, The University of Minnesota, St. Paul, MN, USA |
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| Abstract: | Background Network reconstruction methods that rely on covariance of expression of transcription regulators and their targets ignore the fact that transcription of regulators and their targets can be controlled differently and/or independently. Such oversight would result in many erroneous predictions. However, accurate prediction of gene regulatory interactions can be made possible through modeling and estimation of transcriptional activity of groups of co-regulated genes. |
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