Protein evolution on a human signaling network |
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Authors: | Qinghua Cui Enrico O Purisima Edwin Wang |
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Affiliation: | (1) Biotechnology Research Institute, National Research Council Canada, Montreal, Quebec, Canada;(2) Center for Bioinformatics, McGill University, Montreal, Quebec, Canada;(3) Department of Medical Informatics, Peking University Health Science Center, Beijing, PR, China |
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Abstract: | Background The architectural structure of cellular networks provides a framework for innovations as well as constraints for protein evolution. This issue has previously been studied extensively by analyzing protein interaction networks. However, it is unclear how signaling networks influence and constrain protein evolution and conversely, how protein evolution modifies and shapes the functional consequences of signaling networks. In this study, we constructed a human signaling network containing more than 1,600 nodes and 5,000 links through manual curation of signaling pathways, and analyzed the d N/d S values of human-mouse orthologues on the network. |
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