Genetic determination of the neurophysiological mechanisms of the cortico-subcortical integration of bioelectrical activity of the brain

Contribution of genetical factors to neurophysiological mechanisms of cortico-subcortical integration was investigated in 12 pairs of the monozygotic and 5 pairs of dizygotic twins (aged from 18 to 25). In each pair of twins as well as in all 544 unrelated pairs of subjects from both groups, interpairs similarity of the character of the spatial interaction of bioelectrical activity of the neocortex for different combinations of statistical correlations of EEG (from 16 monopolar electrodes) was estimated. The data obtained allow to suggest a higher common population invariance and a relatively small hereditary and phenotypic variability of morphofunctional systems, which underlie neurophysiological mechanisms of the brain integration in general. Apparently, the formation of the brain stem and subcortical regulatory structures in the ontogenesis, the structures that play the main role in the realization of system combination of different parts of the brain into united formation, occurs to all individuals according to a single principle since its disturbance can probably affect the fundamental monomorphal features of the species. In turn, one can expect a great interindividual variability of establishing of the intraregional connections of neocortex, the role of genetic and environmental factors in the formation of short and relatively long interactions being complex.