B细胞Toll样受体的表达和功能

Toll样受体(TLRs)广泛表达于固有免疫和获得性免疫系统.它们通过识别内外源性致病原含有的保守病原体相关模式分子,启动宿主防卫反应.TLRs也是沟通固有免疫和获得性免疫反应,尤其是T细胞介导的细胞免疫反应的重要桥梁.新近研究表明,几乎所有亚型TLR均表达在B淋巴细胞,不仅参与B细胞增殖、成熟和功能调节,而且在系统性红斑狼疮和慢性淋巴细胞白血病等疾病发生过程中发挥重要调节作用.以TLRs为靶点,调节B细胞介导的免疫反应,可能成为具有崭新应用前景的免疫治疗途径和方法.

Expression and function of toll-like receptors in B lymphocytes

Toll-like receptors (TLRs) are widely expressed in the innate and adaptive immune system. They initiate host defense against endogenous and exogenous pathogens containing conserved pathogen associated molecular patterns. TLRs are critical bridges between the innate and adaptive immunity, especially the cellular immunity mediated by T cells. Emerging evidence indicated that B cells express almost all subtypes of TLRs. TLRs play critical role not only in regulation of proliferation, maturation and function of B cells, but also in pathogenesis of diseases, such as systemic lupus erythematosus and chronic lymphocytic leukemia. Targeting TLRs of B cells is a promising therapeutic strategy for these disorders.