Fatty acid utilization by young Wistar rats fed a cafeteria diet |
| |
Authors: | M. Esteve I. Rafecas J.A. Fernández-López X. Remesar M. Alemany |
| |
Affiliation: | (1) Departament de Bioquímica i Fisiologia, Facultat de Biologia, Universitat de Barcelona, Av. Diagonal, 645, 08028 Barcelona, Spain |
| |
Abstract: | The content and accretion of fatty acids in 30, 45 and 60-day old Wistar rats fed either reference chow or a cafeteria diet has been studied, together with their actual fatty acid intake during that period. Diet had a small overall effect on the pattern of deposition of fatty acids, but the deposition of fat was much higher in cafeteria rats. The fat-rich cafeteria diet allowed the direct incorporation of most fatty acids into lipid storage, whilst chow-feeding activated lipogenesis and the deposition of a shorter chain and more saturated type of fatty acids. During the second month of the rat's life, the elongation pathway as well as 9-desaturase became functional, thus helping to shape the pattern of fatty acids actually accrued. The 60-day rats showed a relative impairment in the operation of 5-desaturase, since their lipids had a higher C20:4/C20:3 ratio than those of the diet ingested. Cafeteria-diet feeding minimized this effect since the large supply of dietary polyunsaturated fatty acids made the operation of the elongation-desaturase pathways practically unnecessary. |
| |
Keywords: | fatty acid cafeteria diet /content/p637372m06q25761/xxlarge916.gif" alt=" Delta" align=" BASELINE" BORDER=" 0" >6-desaturase obesity body fat monounsaturated fatty acids polyunsaturated fatty acids |
本文献已被 SpringerLink 等数据库收录! |
|