Expression of genes related to the hypothalamic-pituitary-adrenal axis in murine fetal lungs in late gestation |
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| Authors: | Marc Simard Mélissa Côté Pierre R Provost Yves Tremblay |
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| Affiliation: | 1.Reproduction, Perinatal Health, and Child Health,CHUQ Research Center,Québec City,Canada;2.Centre de Recherche en Biologie de la Reproduction (CRBR),Laval University,Québec City,Canada;3.Department of Obstetrics and Gynecology, Faculty of Medicine,Laval University,Québec City,Canada |
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| Abstract: | Background Lung maturation is modulated by several factors, including glucocorticoids. Expression of hypothalamic-pituitary-adrenal (HPA) axis-related components, with proposed or described local regulatory systems analogous to the HPA axis, was reported in peripheral tissues. Here, HPA axis-related genes were studied in the mouse developing lung during a period overlapping the surge of surfactant production. |
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