| 纤毛虫中的编程性翻译移码 |
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| 引用本文： | 李禄琴,胡苗清,梁爱华. 纤毛虫中的编程性翻译移码[J]. 生命的化学, 2014, 0(5): 708-714 |
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| 作者姓名： | 李禄琴 胡苗清 梁爱华 |
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| 作者单位： | 山西大学生物技术研究所化学生物学与分子工程教育部重点实验室,太原030006 |
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| 基金项目： | 国家自然科学基金项目（31372199;31272100）;山西省回国留学人员科研项目（2012-重点1） |
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| 摘 要： | 编程性翻译移码现象存在于病毒、原核生物和真核生物中。单细胞真核生物游仆虫基因组中含有的编程性翻译移码基因远远高于其他真核生物基因组。游仆虫中已经报道的编程性翻译移码基因的滑动序列特征为AAA-UAR-V,其上游都有SD(Shine-Dalgarno sequence)相似序列CAAGAA。同时,编程性移码的发生受肽链释放因子eRF1和tRNALys的影响。
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| 关 键 词： | 纤毛虫 编程性翻译移码 基因表达 |
Programmed translational frameshifting in ciliates |
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| LI Luqin,HU Miaoqing,LIANG Aihua. Programmed translational frameshifting in ciliates[J]. Chemistry of Life, 2014, 0(5): 708-714 |
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| Authors: | LI Luqin HU Miaoqing LIANG Aihua |
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| Affiliation: | (Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Biotechnology, Shanxi University, Taiyuan 030006, China) |
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| Abstract: | Programmed translational frameshifting has been identified in a broad range of organisms, including prokaryotes, eukaryotes and virus. According to statistics, among all of the organisms the Euplotes harbor the highest frequency of frameshifting except virus. The slippery sequence of frameshifting gene is AAA-UAR-V in euplotes. The up-stream of the slippery sequence has the SD-like sequence CAAGAA. Also, the occurrence of frameshift is related with the eRF1 and tRNA. |
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| Keywords: | ciliate programmed translational frameshifting gene expression |
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