有丝分裂激酶Aurora B的研究进展

真核生物细胞通过有丝分裂将遗传物质均等地分配到两个子细胞中,从而维持基因组的稳定性。有丝分裂的每一环节都需要精准而细致的调控,这依赖于一系列调节机制,尤其需要多个相关激酶的共同协调。Aurora B是一个关键的有丝分裂调控激酶,伴随有丝分裂的进行,其先后在染色体臂、内着丝粒、中央纺锤体、中体上动态分布。与其高度时空动态性相一致的是,Aurora B在有丝分裂的多个环节,如姐妹染色体粘连、动粒微管连接、纺锤体检验点和胞质分裂过程中都发挥着一系列重要功能。本文将概述近年来Aurora B激酶功能与调控方面的研究进展。

Research progress of dissecting Aurora B kinase

Equally partition of sister chromatids into two daughter cells in mitosis is a key event to maintain the genomic stability of organisms. Faithful mitotic progression is ensured by many regulatory mechanisms, especially the multiple mitotic kinases. Aurora B is one of the master kinases of mitosis. Consistent with its dynamical distributions on chromosome arm, inner centromere, central spindle and midbody, Aurora B regu- lates multiple events including sister-chromatid cohesion, kinetochore-microtubule attachment, spindle assem- bly checkpoint and cytokinesis. We have reviewed the recent research progress of the function and regulation of Aurora B kinase.