| 透明质酸在肿瘤治疗中的应用 |
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| 引用本文： | 王天琪,张娜. 透明质酸在肿瘤治疗中的应用[J]. 生命的化学, 2014, 0(5): 690-695 |
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| 作者姓名： | 王天琪 张娜 |
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| 作者单位： | 山东大学药学院,济南250012 |
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| 基金项目： | 山东大学基本科研业务费资助项目自然科学专项（前沿和新兴学科团队导向类项目）（2014QY004） |
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| 摘 要： | 透明质酸(hyaluronic acid,HA)是脊椎动物细胞间基质的重要组成成分,它是一种线性生物多聚糖,具有良好的生物相容性、生物可降解、无毒、无免疫原性等特点,在生物医药领域有广泛的应用。本文简要介绍透明质酸的结构特点及其靶向作用机制,综述近年来透明质酸作为药物载体和靶向因子在肿瘤治疗中的研究现状。
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| 关 键 词： | 透明质酸 肿瘤治疗 药物递送载体 靶向配体 |
Application of hyaluronic acid in cancer therapy |
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| WANG Tianqi,ZHANG Na. Application of hyaluronic acid in cancer therapy[J]. Chemistry of Life, 2014, 0(5): 690-695 |
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| Authors: | WANG Tianqi ZHANG Na |
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| Affiliation: | (Institute ofPharmaceutics, Shandong University, Ji＇nan 250012, China) |
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| Abstract: | Hyaluronic acid （HA） is an important constituent of the extracellular matrix in vertebrates. It is a linear polysaccharide with biodegradation, biocompatibility, low toxicity, and no immunogenicity, and has been extensively used in biomedical field. In this paper, the structure and targeting mechanism of HA are in- troduced, and the recent advance of HA on chemotherapy drug, gene delivery carders or targeting ligands in cancer therapy are summarized. |
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| Keywords: | hyaluronic acid cancer therapy drug delivery carrier targeting ligand |
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