| 中药成分对氟康唑抗非白色念珠菌的增效作用 |
| |
| 引用本文： | 王维欣,;孙淑娟. 中药成分对氟康唑抗非白色念珠菌的增效作用[J]. 生命的化学, 2014, 0(6): 812-816 |
| |
| 作者姓名： | 王维欣, 孙淑娟 |
| |
| 作者单位： | [1]山东大学药学院,济南250012; [2]山东省泰山医院药剂科,泰安271000; [3]山东大学附属千佛山医院,济南250014 |
| |
| 基金项目： | 山东省中医药科技发展计划（2013-196）; 山东省科技发展计划（2013GSF11848） |
| |
| 摘 要： | 近年来,对氟康唑敏感性差的非白色念珠菌的分离率逐渐上升,而现有的抗真菌药品种少,且大多价格昂贵、或毒副作用大,使它们的临床应用受到限制。因此联合用药特别是与中药联合成为研究热点。研究表明,有些中药成分与氟康唑联合具有协同抗真菌作用。该文就中药成分与氟康唑联合抗非白色念珠菌作用及机制的研究进展进行综述,旨在为新型抗真菌药物的研究提供参考。
|
| 关 键 词： | 中药成分 氟康唑 协同作用 非白色念珠菌 联合作用机制 |
Research progress of the synergistic effect of traditional Chinese medicine ingredient and fluconazole against non-Candida aibicans |
| |
| Affiliation: | WANG Weixin, SUN Shujuan. (1.School of Pharmaceutical Sciences, Shandong University, Ji＇nan 250012, China; 2Department of Pharmacy, Shandong Provincial Taishan Hospital, Tai＇an 271000, China 3Qianfoshan Hospital Affiliated to Shandong University, Ji＇nan 250014, China) |
| |
| Abstract: | For the past few years, non-Candida albicans which bearing poor sensitivity to fluconazole are isolated frequently, while the available anti-fungal agents are limited for its high price or toxicity. Thus, com- bination approach especially with Traditional Chinese medicines （TCM） has become a research hotspot. It has been reported that some of the ingredients of TCM show synergistic antifungal effect with fluconazole. In this review, we review the synergistic effects of TCM and fluconazole against non-Candida albicans as well as the related mechanisms, so as to provide references for the development of novel antifungal drugs. |
| |
| Keywords: | Chinese native medicine ingredient fluconazole synergism non-Candida albicans synergis-tic mechanism |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
