| APOBEC3F蛋白的结构与功能 |
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| 引用本文： | 欧阳昌鑫,;卢秀秀,;赵玢,;蓝文贤,;朱爱萍.APOBEC3F蛋白的结构与功能[J].生命的化学,2014(6):725-731. |
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| 作者姓名： | 欧阳昌鑫 ;卢秀秀 ;赵玢 ;蓝文贤 ;朱爱萍 |
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| 作者单位： | [1]扬州大学化学与化工学院,扬州225002; [2]中国科学院上海有机化学研究所,生命有机化学国家重点实验室,上海200032 |
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| 基金项目： | 国家重点基础研究发展计划（“973”计划）项目（2011CB966300） |
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| 摘 要： | 载脂蛋白B mRNA编辑酶催化多肽样蛋白3F(apolipoprotin B mRNA-editing catalytic polypeptide 3protein F,APOBEC3F,简称A3F)是一种天然抗病毒活性的胞嘧啶脱氨基酶。在HIV病毒复制过程中,A3F蛋白能被整合进入病毒颗粒内部,诱导病毒c DNA胞嘧啶脱氨基化变为尿嘧啶,阻断病毒复制。近几年,科研工作者开展了一系列A3F蛋白的结构生物学和脱氨基化反应的研究,以及与单链DNA(single-stranded DNA,ss-DNA)的结合位点、病毒感染因子(viral infectivity factor,Vif)作用界面的探索。本文通过对这些工作进行总结,以期为艾滋病、乙肝的防治提供新的理论基础。
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| 关 键 词： | A3F HIV Vif 胞嘧啶 脱氨基酶 |
Research progress of the structure and function of A3F |
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| Institution: | OUYANG Changxin, LU Xiuxiu, ZHAO Bin, LAN Wenxian, ZHU Aiping (1College of Chemistry And Chemical Engineering, Yangzhou University, Yangzhou 225000, China; 2State Key Lab of Bio-Organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China) |
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| Abstract: | Apolipoprotin B mRNA-editing catalytic polypeptide 3 protein F （APOBEC3F） （A3F） belongs to a family of poly nucleotide cytidine deaminases. During the process of HIV virions replication, A3F is effec- tively incorporated into budding HIV-1 virions, catalyzes C-U conversions, and then blocks viral replication. In recent years, much attention has been paid to the structure and the process of deamination of APOBEC3F, binding sites of ss-DNA and interface with Vif. In this paper, we review these works in order to provide new insights for possible prevention of AIDs and hepatitis B virus infection. |
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| Keywords: | A3F HIV Vif cytidine deaminase |
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