Neuropathogenesis of influenza virus infection in mice |
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Authors: | Mori I Kimura Y |
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Affiliation: | Department of Microbiology, Fukui Medical University School of Medicine, Fukui 910-1193, Japan. |
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Abstract: | The neurovirulent WSN strain of influenza A virus, introduced into the olfactory bulb of C57BL/6 mice, selectively attacks several brain nuclei which are highly implicated in the pathogenesis of neuropsychiatric disturbances. The virus-infected neurons are eradicated through apoptotic neurodegeneration. On the other hand, activated microglia serve the neuroprotection against virus infection. |
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