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The state of melanoma: challenges and opportunities
Authors:Glenn Merlino  Meenhard Herlyn  David E Fisher  Boris C Bastian  Keith T Flaherty  Michael A Davies  Jennifer A Wargo  Clara Curiel‐Lewandrowski  Michael J Weber  Sancy A Leachman  Maria S Soengas  Martin McMahon  J William Harbour  Susan M Swetter  Andrew E Aplin  Michael B Atkins  Marcus W Bosenberg  Reinhard Dummer  Jeffrey E Gershenwald  Allan C Halpern  Dorothee Herlyn  Giorgos C Karakousis  John M Kirkwood  Michael Krauthammer  Roger S Lo  Georgina V Long  Grant McArthur  Antoni Ribas  Lynn Schuchter  Jeffrey A Sosman  Keiran S Smalley  Patricia Steeg  Nancy E Thomas  Hensin Tsao  Thomas Tueting  Ashani Weeraratna  George Xu  Randy Lomax  Alison Martin  Steve Silverstein  Tim Turnham  Ze'ev A Ronai
Institution:1. Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA;2. Melanoma Research Center, The Wistar Institute, Philadelphia, PA, USA;3. Department of Dermatology, Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA, USA;4. Departments of Dermatology and Pathology, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA;5. Developmental Therapeutics, Cancer Center, Massachusetts General Hospital, Charlestown, MA, USA;6. Department of Genomic Medicine and Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;7. Departments of Medicine and Dermatology, University of Arizona Cancer Center, Tucson, AZ, USA;8. Department of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA, USA;9. Department of Dermatology, Knight Cancer Institute Melanoma and Skin Cancer Program, Oregon Health Science University, Portland, OR, USA;10. Molecular Oncology Program, Melanoma Laboratory, CNIO, Madrid, Spain;11. Department of Dermatology, Huntsman Cancer Institute, Salt Lake City, UT, USA;12. Bascom Palmer Eye Institute and Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA;13. Department of Dermatology, Stanford University Medical Center and Cancer Institute/VA Palo Alto Health Care System, Palo Alto, CA, USA;14. Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA;15. Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA;16. Department of Dermatology and Dermatopathology, Cancer Center, Yale University, New Haven, CT, USA;17. Department of Dermatology, University of Zurich, Zürich, Switzerland;18. Dermatology, Memorial Sloan Kettering Cancer Center, New York, NY, USA;19. Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA;20. Melanoma and Skin Cancer Program, University of Pittsburgh, Pittsburgh, PA, USA;21. Department of Pathology, Cancer Center, Yale University, New Haven, CT, USA;22. Department of Medical Oncology and Dermatology, University of California Los Angeles, Los Angeles, CA, USA;23. Melanoma Institute, University of Sydney, Sydney, NSW, Australia;24. Department of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, Vic., Australia;25. Department of Medicine, Vanderbilt‐Ingram Cancer Center, Vanderbilt University Medical School, Nashville, TN, USA;26. Department of Tumor Biology, The Moffitt Cancer Center & Research Institute, Tampa, FL, USA;27. Women Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA;28. Melanoma Program, Department of Dermatology, Lineberger Cancer Center, University of North Carolina, Chapel Hill, NC, USA;29. Melanoma and Pigmented Lesion Center, Massachusetts General Hospital, Charlestown, MA, USA;30. Department of Dermatology, University of Bonn, Bonn, Germany;31. Melanoma Research Foundation, Washington, DC, USA;32. Tumor Initiation and Maintenance Program, Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA
Abstract:The Melanoma Research Foundation (MRF) has charted a comprehensive assessment of the current state of melanoma research and care. Intensive discussions among members of the MRF Scientific Advisory Council and Breakthrough Consortium, a group that included clinicians and scientists, focused on four thematic areas – diagnosis/early detection, prevention, tumor cell dormancy (including metastasis), and therapy (response and resistance). These discussions extended over the course of 2015 and culminated at the Society of Melanoma Research 2015 International Congress in November. Each of the four groups has outlined their thoughts as per the current status, challenges, and opportunities in the four respective areas. The current state and immediate and long‐term needs of the melanoma field, from basic research to clinical management, are presented in the following report.
Keywords:melanoma  prevention  early   diagnosis  metastasis  dormancy  therapy
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