Antigenotoxic activity of biologically active substances from <Emphasis Type="Italic">Inula britannica</Emphasis> and <Emphasis Type="Italic">Limonium gmelini</Emphasis> |
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| Authors: | A V Lovinskaya S Zh Kolumbayeva T M Shalakhmetova M V Marsova S K Abilev |
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| Institution: | 1.Al-Farabi Kazakh National University,Almaty,Kazakhstan;2.Vavilov Institute of General Genetics,Russian Academy of Sciences,Moscow,Russia;3.Department of Genetics,Moscow State University,Moscow,Russia |
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| Abstract: | The antigenotoxic and antioxidant activities of biologically active substances of extracts from Inula britannica L. and Limonium gmelinii (Willd.) Kuntze in E. coli strains MG1655 (pColD-lux), MG1655 (pSoxS-lux), and MG1655 (pKatG-lux) were studied by the bioluminescent test. Plant extracts from I. britannica and L. gmelinii in all used concentrations (0.5, 5.0, 50.0, and 500.0 μg/mL) had no genotoxic or oxidant activity. The extracts statistically significantly reduced the bioluminescence intensity of the pColD-lux, pKatG-lux, and pSoxS-lux sensors (p < 0.05) induced by 4-NQO and dioxidine, hydrogen peroxide, and paraquat, respectively. The activity of the extracts depended on their concentration; the greatest antigenotoxic and antioxidant effects were detected at a concentration of 500.0 μg/mL. |
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