Search for genetic markers of climatic adaptation in populations of North Eurasia |
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| Authors: | V A Stepanov V N Kharkov K V Vagaitseva A V Bocharova A Yu Kazantsev A A Popovich I Yu Khitrinskaya |
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| Institution: | 1.Institute of Medical Genetics,Tomsk National Medical Research Center,Tomsk,Russia;2.Department of Cytology and Genetics,National Research Tomsk State University,Tomsk,Russia;3.Tomsk Polytechnic University,Tomsk,Russia |
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| Abstract: | Genetic diversity of native populations of North Eurasia is investigated using a panel of genetic markers of candidate genes for cold climate adaptation. A high level of within- and between-population variability is detected. Comparative analysis of data on North Eurasian populations combined with data on worldwide populations from the 1000 Genomes and HDGP projects reveals correlations of genetic diversity in candidate genes for cold climate adaptation with key climate parameters, as well as the increase of genetic diversity in markers of this group of genes with the increase of latitude, that is, as modern humans migrated out of Africa. Using the method of searching for extreme empirical values of the coefficient of genetic diversity, signals of directional selection for markers of six genes adaptive to cold (MYOF, LONP2, IFNL4, MKL1, SLC2A12, and CPT1A) are found. The data are discussed in framework of the hypothesis of decanalization of genome–phenome relationships under the pressure of natural selection during human settlement throughout the world. |
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