The DAPIN family: a novel domain links apoptotic and interferon response proteins |
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Authors: | Staub E Dahl E Rosenthal A |
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Affiliation: | metaGen Gesellschaft für Genomforschung mbH, 14195, Berlin, Germany. eike.staub@metagen.de |
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Abstract: | We report the discovery of a protein domain, hereafter referred to as DAPIN, in diverse vertebrate and viral proteins that is associated with tumor biology, apoptosis and inflammation. Based on a secondary structure prediction, we suggest an all-alpha fold for DAPIN, which is also adopted by apoptotic protein domains of the CARD, death domain and death effector domain type. |
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