Catechol derivatives of aminopyrazine and cell protection against UVB-induced mortality |
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| Authors: | Cavalier J F Burton M Dussart F Marchand C Rees J F Marchand-Brynaert J |
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| Institution: | Unité de Chimie Organique et Médicinale, Université catholique de Louvain, Batiment Lavoisier, Louvain-la-Neuve, Belgium. |
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| Abstract: | A series of 5-aryl- and 3,5-bis-aryl-2-amino-1,4-pyrazine derivatives 4 and 6, and related imidazolopyrazinones 7, has been synthesized, the aryl groups of which are catechol and/or phenol substituents. These compounds, tested against human keratinocyte cells stressed by UVB irradiation, showed high antioxidative properties. One compound (6f) was more active than EGCG/ECG (green tea extract) in reducing cell mortality. |
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