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Molecular profile and copy number analysis of sporadic colorectal cancer in Taiwan |
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| Authors: | Chien-Hsing Lin Jen-Kou Lin Shih-Ching Chang Ya-Hui Chang Hwey-May Chang Jin-Hwang Liu Ling-Hui Li Yuan-Tsong Chen Shih-Feng Tsai Wei-Shone Chen |
| Institution: | (1) Division of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Taiwan;(2) Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan;(3) Division of Hematology and Oncology, Taipei Veterans General Hospital, Taipei, Taiwan;(4) Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan;(5) Genome Research Center and Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan |
| Abstract: | BackgroundColorectal cancer (CRC) is a major health concern worldwide, and recently becomes the most common cancer in Asia. The case collection of this study is one of the largest sets of CRC in Asia, and serves as representative data for investigating genomic differences between ethnic populations. We took comprehensive and high-resolution approaches to compare the clinicopathologic and genomic profiles of microsatellite instability (MSI) vs. microsatellite stability (MSS) in Taiwanese sporadic CRCs. |
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