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Quantitative regulation of histone variant H2A.Z during cell cycle by ubiquitin proteasome system and SUMO-targeted ubiquitin ligases |
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| Authors: | Daisuke Takahashi Yuki Orihara Saho Kitagawa Masayuki Kusakabe Takahiro Shintani Yukako Oma |
| Institution: | 1. Laboratory of Molecular Biology, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan;2. Laboratory of Bioindustrial Genomics, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan |
| Abstract: | Quantitative control of histones and histone variants during cell cycle is relevant to their epigenetic functions. We found that the level of yeast histone variant H2A.Z in the G2/M-phase is actively kept low by the ubiquitin proteasome system and SUMO-targeted ubiquitin ligases. Overexpression of H2A.Z induced defects in mitotic progression, suggesting functional importance of this quantitative control. |
| Keywords: | chromatin histone H2A Z SUMO-targeted ubiquitin ligases |