Synthesis characterization and cytotoxicity studies of platinum(II) complexes with reduced amino pyridine schiff base and its derivatives as ligands |
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| Authors: | Li-Jun Li Qin-Qin Yan Guo-Jun Liu Zhen Yuan Zhen-Hua Lv Bin Fu |
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| Institution: | Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding, P.R. China |
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| Abstract: | A series of reduced amino pyridine Schiff base platinum(II) complexes were prepared as potential anticancer drugs, and characterized by NMR, IR spectroscopy, elemental analysis, and molar conductivity. UV and CD results showed the binding mode between these compounds and salmon sperm DNA may be intercalation. The cytotoxicity of these complexes was validated against A549, Hela, and MCF-7 cell lines by MTT assay. Some complexes exhibited better cytotoxic activity than cisplatin against Hela and MCF-7 cell lines. |
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| Keywords: | platinum(II) complexes reduced amino pyridine Schiff base DNA interaction antitumor activity |
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