Recent developments in chromatographic purification of biopharmaceuticals |
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Authors: | Anurag S Rathore Devashish Kumar Nikhil Kateja |
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Institution: | 1.Department of Chemical Engineering, DBT Center of Excellence for Biopharmaceutical Technology,Indian Institute of Technology, Delhi,New Delhi,India |
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Abstract: | Over the last several decades, researchers have time and again proposed use of non-chromatographic methods for processing of biotherapeutic products. However, chromatography continues to be the backbone of downstream processing, particularly at process scale. There are many reasons for this, critical ones being the unparalleled scalability, robustness, and selectivity that process chromatography offers over its peers. It is no surprise then that process chromatography has been a topic of major developments in resin matrix, ligand chemistry, modalities, high throughput process development, process modelling, and approaches for control. In this review, we attempt to summarize major developments in the above-mentioned areas. Greater significance has been given to advancements in the last 5 years (2013–2017). |
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