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Short-step syntheses of naturally occurring polyoxygenated aromatics based on site-selective transformation |
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| Authors: | Yasunobu Yamashita Alan Biard Kengo Hanaya Mitsuru Shoji |
| Institution: | 1. Department of Pharmaceutical Sciences, Faculty of Pharmacy, Keio University, Tokyo, Japan;2. Department of Chemistry, Graduate School of SIGMA Clermont, Aubiere Cedex, France |
| Abstract: | Wogonin and astringin were synthesized from inexpensive chrysin and piceid in short steps. The key feature of these syntheses is site-selective transformation. The target molecules were obtained in 27 and 62% yields from the starting materials, respectively. |
| Keywords: | wogonin astringin site-selective acetylation site-selective deacetylation hydroxylation |