Lutein,a carotenoid,suppresses osteoclastic bone resorption and stimulates bone formation in cultures |
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| Authors: | Tsukasa Tominari Chiho Matsumoto Kenta Watanabe Michiko Hirata Florian M.W. Grundler Masaki Inada |
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| Affiliation: | 1. Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo, Japan;2. Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, Tokyo, Japan;3. Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, Tokyo, Japan;4. Institute of Crop Science and Resource Conservation, University of Bonn, Bonn, Germany |
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| Abstract: | Lutein, a member of the xanthophyll family of carotenoids, suppressed IL-1-induced osteoclast differentiation and bone resorption. The survival of mature osteoclasts was also suppressed by lutein in cultures. When lutein was added to the cultures of osteoblasts, lutein enhanced the formation of mineralized bone nodules by elevating BMP2 expression and inhibiting sclerostin expression. Lutein may be beneficial for bone health. |
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| Keywords: | bone resorption bone formation xanthophyll family of carotenoids |
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